Which of the following is a common side effect of NSAIDs?

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to alleviate pain, reduce inflammation, and lower fever. A common side effect associated with their use is stomach upset, or gastrointestinal discomfort. This occurs because NSAIDs can inhibit the production of prostaglandins, compounds that help to protect the stomach lining. When these protective prostaglandins are reduced, the stomach becomes more susceptible to irritation and damage, leading to symptoms like nausea, heartburn, or even ulcers with prolonged use.

While other potential side effects of NSAIDs exist, such as skin rashes, drowsiness, and, in rare cases, weight gain due to fluid retention, stomach upset is the most frequently encountered issue among users. Understanding this side effect is crucial for patients and healthcare providers when considering the use of NSAIDs for pain management.